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Showing 1 to 12 of 2775 entries
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Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria.

Iranian journal of pharmaceutical research : IJPR

Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H.
PMID: 26330870
Iran J Pharm Res. 2015;14(3):825-32.

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of...

A Randomized, Double-blind, Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women: A Pilot Study.

Iranian journal of pharmaceutical research : IJPR

Majd M, Hashemian F, Hosseini SM, Vahdat Shariatpanahi M, Sharifi A.
PMID: 26330878
Iran J Pharm Res. 2015;14(3):891-9.

This study was designed to examine the antidepressant effect of celecoxib (200 mg/day) augmentation of sertraline in the treatment of female patients with first episode of major depression over 8 weeks of therapy. Thirty female outpatients diagnosed with first...

New Product Development in the Pharmaceutical Industry: Evidence from a generic market.

Iranian journal of pharmaceutical research : IJPR

Yousefi N, Mehralian G, Rasekh HR, Yousefi M.
PMID: 28979339
Iran J Pharm Res. 2017;16(2):834-846.

In today's competitive world, there are several strategies to deal with the fast changing environment, among which New product development (NPD) is a common strategy. However, almost half of the resources that companies devote to NPD are spent on...

Effect of Crude Venom of .

Iranian journal of pharmaceutical research : IJPR

Ghasemi S, Salarian AA, Zare Mirakabadi A, Jafarinejad S, Ghazi-Khansari M.
PMID: 28979318
Iran J Pharm Res. 2017;16(2):648-652.

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and...

Iranian journal of pharmaceutical research : IJPR

Ifeoluwa Okeleye B, Mkwetshana NT, Ndip RN.
PMID: 28979326
Iran J Pharm Res. 2017;16(2):714-724.

We evaluated the

QSAR Modeling of COX -2 Inhibitory Activity of Some Dihydropyridine and Hydroquinoline Derivatives Using Multiple Linear Regression (MLR) Method.

Iranian journal of pharmaceutical research : IJPR

Akbari S, Zebardast T, Zarghi A, Hajimahdi Z.
PMID: 28979307
Iran J Pharm Res. 2017;16(2):525-532.

COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure-activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R

Nano Liposomes Labeled with (99m)Tc-HMPAO, a Novel Agent for Blood Pool Imaging.

Iranian journal of pharmaceutical research : IJPR

Sadri K, Momenypoor S, Dabbagh Kakhki VR, Sadeghi R, Aryana K, Johari Daha F, Zakavi SR, Jaafari MR.
PMID: 26664365
Iran J Pharm Res. 2015;14(4):981-8.

In-vitro labeling of RBC with (99m)Tc is an intricate procedure and there is always a need for an alternate blood pool imaging agent. The aim of this study was to prepare an effective nano sized liposome (NLs) similar to...

Electrochemical Synthesis and Kinetic Evaluation of Electrooxidation of Acetaminophen in the Presence of Antidepressant Drugs.

Iranian journal of pharmaceutical research : IJPR

Nematollahi D, Feyzi Barnaji B, Amani A.
PMID: 26664378
Iran J Pharm Res. 2015;14(4):1115-22.

With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs...

The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat.

Iranian journal of pharmaceutical research : IJPR

Rahimi HR, Ghahremani MH, Dehpour AR, Sharifzadeh M, Ejtemaei-Mehr S, Razmi A, Ostad SN.
PMID: 26664379
Iran J Pharm Res. 2015;14(4):1123-35.

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate the cannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this are unclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2) and downstream GSK-3β pathways...

The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovarian Syndrome in Rat.

Iranian journal of pharmaceutical research : IJPR

Ghafurniyan H, Azarnia M, Nabiuni M, Karimzadeh L.
PMID: 26664389
Iran J Pharm Res. 2015;14(4):1215-33.

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which the level of oxidative elements in blood rises. Green tea is a potent antioxidant since it contains catechins. In this study, the effect of hydro-alcoholic green tea...

Phenolic Derivatives of Artemisia Spicigera C. Koch Growing in Iran.

Iranian journal of pharmaceutical research : IJPR

Heshmati Afshar F, Delazar A, Nazemiyeh H, Khodaie L, Bamdad Moghaddam S.
PMID: 26664392
Iran J Pharm Res. 2015;14(4):1241-6.

This study aimed to determine phenolic compounds of Artemisia spicigera (family Asteraceae) growing in East-Azarbaijan province of Iran. 20%, 40 % and 60% SPE fractions of methanolic extract of A. spicigera, were subjected to reversed phase preparative HPLC, with...

Amitriptyline 2% cream vs. capsaicin 0.75% cream in the treatment of painful diabetic neuropathy (Double blind, randomized clinical trial of efficacy and safety).

Iranian journal of pharmaceutical research : IJPR

Kiani J, Ahmad Nasrollahi S, Esna-Ashari F, Fallah P, Sajedi F.
PMID: 26664395
Iran J Pharm Res. 2015;14(4):1263-8.

Because of less systemic side effects of topical medications in pain relief of the painful form of diabetic peripheral neuropathy, this study aimed to compare the effect of amitriptyline and capsaicin cream in relieving pain in this condition. In...

Showing 1 to 12 of 2775 entries